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For instance, in the 'gene expression, cancer and cell morphology' network, miR-218 may target genes directly and indirectly linked to two oncogenes, MYC and SRC (Figure S4).
Current research suggests that microRNAs (miRNAs) degrade and repress translation of mRNA, but also may target genes involved in differentiation.
Our analyses identified some phasiRNAs that may target genes outside the gene families of their originating loci.
Further, these alterations may target genes that regulate stem cells and prevent differentiation of their daughter cells.
We have addressed this problem by systemically estimating the possible miRNAs that may target genes deregulated during disease progression (Additional file 1).
Identification of these miR provide an initial group of expressed miR that change in abundance during specific developmental stages and therefore may target genes that regulate this process.
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This result shows that NMD may target different genes in different species, but these genes often belong to the same functional categories.
While a number of miRNAs may target numerous genes, the processing of miRNAs to maturity is regulated by a relatively small set of genes.
These findings point to the fact that upregulation of specific miRNAs may target particular genes that are important for tissue-specific aging decline.
In particular, miR-219-5p miR-219-5p miR-219-5pet 5–6 genes andociated with these functions.
Together miR-21, miR-24 and miR-205 may target 66 genes (Additional file 2A).
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