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This suggests that thioester domains may target distinct receptors and have a widespread but currently unappreciated role in mediating pathogen adhesion to hosts.
Our results rather suggest that the two MEK isoforms may be differentially regulated or may target distinct effector pathways in certain cellular and/or genetic contexts.
Surprisingly our data suggest a novel model for how FAK regulates cellular signal transduction with important implications for understanding the role of FAK in multiple cell types and how distinct therapeutic interventions may target distinct FAK signaling actions.
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Eradication of additional lipid droplets by the combined supplementations of DHA and lysine suggests that DHA and/or lysine may target mechanisms distinct from those of energy homeostasis in hepatic lipid metabolism.
Therefore, the implementation of rational, multiagent treatments that target distinct pathways may circumvent these tumor survival strategies.
Simply mixing different PDT PSs, even those that target distinct receptors (this may still lead to similar cell-killing pathways), may not achieve ideal therapeutic outcomes.
Novel mutations target distinct subgroups of medulloblastoma.
This analysis suggests that miR-151a-3p miR-151a-3p miR-151a-3p48 may target similar, yet distinct signandng pathways imayrtargetor the aging procesimilar
In addition, the substrate-trap SptPD441A was absent from SCVs, implying that SptP may target VCP at membranes distinct from the SCV.
Parallel immunofluorescence revealed that, unlike SptPWT, the substrate-trap SptPD441A was absent from SCVs and localized diffusely throughout the perinuclear region, implying that SptP may target VCP at membranes distinct from the SCV.
Recent results, however, suggest that Id1 may target unique pathways that are distinct from Id3: Id1 but not Id3 appears to direct long-term repopulating hematopoietic stem cell maintenance [ 21].
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CEO of Professional Science Editing for Scientists @ prosciediting.com