For this application, anti-DEC-205 antibodies may be used to target compounds specifically to DCs or to selectively target ECs, and (peptide) inhibitors can be coupled to a multimodular recombinant protein that specifically binds to cytokine-activated endothelium, which has been demonstrated to work very elegantly under inflammatory conditions in vivo [ 94].
The garlic compounds may target one or more loss-of-function pathways in cancer cells.
It seems different compounds may target different chemokine signaling pathways.
Despite the pivotal role that growth and aging play in neurodegenerative disease, we found that LiCl and MTR protect C. elegans neurons in the absence of growth and through a daf-16 independent pathway suggesting that these compounds may target pathways that are specific to neurodegeneration.
Hence, these compounds may target one or more processes in the cell that generate phenotypes distinct from, or in addition to, a specific developmental response.
Since normal cells are not generally as sensitive as tumor cells to sesquiterpene lactones due to low basal NF-κB activity, these compounds may target cancers in which the NF-κB pathway is constitutively activated.
Coal tar comprises at least 10,000 high-molecular-weight hydrocarbon and aromatic compounds, which may target the AhR/ARNT system.
It may target Hollywood next.
Hence, in this work we describe a computational method for the design of synthetically feasible ligands that bind to A1 and A2A receptors and inhibit phosphodiesterase 10A (PDE10A), involving a retrosynthetic approach employing in silico target prediction and docking, which may be generally applicable to multi-target compound design at several target classes.
Nevertheless, excessive expression of heterologous genes usually leads to severe metabolic stress on the host, and the increased intracellular accumulation of target compounds may be harmful to the cell metabolism simultaneously.
