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Since previous studies have shown that recombinant TIMP-1 and TIMP-2 inhiboned bone resorption in vitro (Hill et al, 1993), TIMP-2 may suppress bone metastasis by inhibiting both tumour invasion and bone resorption.
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25 EHDP in large doses may also suppress bone turnover, inhibits bone mineralization and affect tooth development, deleterious effects that discourage general use.
Recent findings suggest that bisphosphonates may also indirectly suppress bone resorption through their action on osteoblasts [ 2], and osteocytes [ 3], which could represent another target for these drugs.
22 28 Higher doses of vitamin D than were used in the existing trials may be needed to suppress bone turnover if calcium is not co-administered.
Arsenic and lead also may inhibit bone formation., "Each time I find that a chemical can suppress bone formation I become more intrigued and concerned with the idea that common environment contaminants are contributing to the onset or exacerbation of osteoporosis," Schlezinger adds.
In contrast, zoledronic acid could effectively suppress bone resorption and prevent bone loss.
These medications suppress bone resorption, maintain bone mass, and prevent bone fractures.
Application of bisphosphonates, which suppress bone turnover, can inhibit bone metastasis [ 11].
Prolonged bisphosphonate treatment might suppress bone remodeling to the extent that normal bone repair is impaired.
A decrease in PTH would be expected to suppress bone resorption, but bone resorption is also stimulated by 1,25(OH)2D.
A proteomic approach was used to show that specific antibodies could suppress bone turnover [ 84].
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