Given that Vasa is expressed by proliferating lineages in a number of different species, it is tempting to speculate that Vasa may also support proliferation of Drosophila SGPs.
In addition to the block of differentiation, RUNX1-CBFA2T1 malsolsupportort proliferation, as, for instance, RUNX1-CBFA2T1-expressing HSCs maintain their telomere lengths and their CD34 expression [ 21].
Taken together, these results indicate that a single growth factor, bFGF, may support PGC proliferation.
During early tumorigenesis, elafin downregulation in the bulk of the tumor may support cell proliferation.
However, oxygen saturated PFD may support hepatocyte proliferation (regeneration) ex vivo.
However, the misuse of SASP factors by cancer cells may support their proliferation and induce a chronic inflammatory response [ 26].
Together, these findings lead to the postulate that ALR may support cell proliferation by influencing NFκB, c-Myc, polyamines, and cytochrome P-450.
Cumulatively, these data indicate that S14 itself is not sufficient to promote a differentiation program in mammary tumors; rather, S14 may support the proliferation or survival of a differentiated mammary tumor cell type.
In contrast, it was also shown that bFGF may support the proliferation of ESFT cells and maintain their malignant phenotype by upregulating the EWS/FLI1 protein under serum-free conditions (Girnita et al, 2000).
Proliferative cues from Ras/MAPK pathway activation may alleviate Hippo activity thereby increasing YAP activity to support proliferation.
