Some material was observed within the flagellar pocket for both knockout cell lines; this may suggest defective lipid or other biosynthetic defects in these cells, but is also observed occasionally in wild type cultures.
Tsc mutant embryos feature phenotypic variability and developmental delay, though, which may suggest earlier defects that are compensated for by regulative mechanisms.
These observations and earlier studies on humans with UC showing bacteria in contact with the epithelium 16 17 may suggest that defects in the inner mucus layer that allow bacteria to reach the epithelium in larger quantities than normal can activate the immune system.
"Given that tickle is associated with the neurological generation of 'self' and 'other,' it may be that individual differences in tickle may suggest a defect in the processing of this information that might exist in some autistic individuals," he says.
In addition, the bacteria specificity could provide some informative clues: Based on some investigations, pneumoccocus or hemophilus may suggest cranial dural defects, E. coli or other gram negative bacillus may suggest spinal dural defects, and meningococcus may suggest immunologic deficiency of the patient [ 3– 5].
In addition, since the abnormal cytokine response to apoptotic material in SLE is not related to disease activity, it is possible that these findings may suggest a primary defect (either genetic or epigenetic) in the immunomodulatory response to apoptotic cells by lupus monocytes.
3) The discovery of specific immune defects may suggest new therapies for neurodevelopmental disorders.
Considering the limited number of genes deregulated in SCNT embryos, one may suggest that a simple defect in the expression of a few genes may translate into defective expression of a great number of genes in a ripple effect.
Recurrent DNAH9 mutations in IMPC, characterised by a polarity defect, may suggest a causative role of these mutations in the IMPC pattern of growth that remains to be demonstrated in vitro.
However, the observation of a dislocation may suggest that the concept of different defect regimes in the P– T– X-space is more complex than previously elaborated.
