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Dialysis may substantially worsen quality of life especially in those with significant co-morbidity.
In a systematic review to assess whether morcellation of occult leiomyosarcomas during surgery to treat presumed myomas may substantially worsen patient outcome, no reliable evidence that morcellation substantially results in tumor upstaging was found [ 20].
Nevertheless, such repetitive practice during a tournament prior to each match is questionable since the long-term safety of intra-articular application may substantially worsen the injury if play is resumed immediately.
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"Of course, the data may well worsen from here.
The situation may well worsen.
For the latter, a borderline socio-economic status may thus become substantially worsened by obstetric complications and has little to do with ethnic profile per se.
"Evidence of terrorism would obviously substantially worsen and prolong the loss of passenger bookings.
A modest increase of high-risk behavior in countries with expanded treatment programs -- like a 10percentt decline in condom use -- could substantially worsen the epidemic.
According to a New York Times article, the report concluded that the pipeline "would not substantially worsen carbon pollution" -- a reading that echoed through environmental and media circles.
A friend who visited him in jail last week said his condition appeared to have substantially worsened.
Finance minister Carlos Costa Pinas says the "cost of financing [the debt] was substantially worsened by the opposition".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com