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One possible mediating pathway involves changes in gene expression that may subsequently influence disease development or resistance.
In particular, this study adopts a multiple mediation approach to examine whether perceived message clarity and perceived CSR vary by cultural difference in response to the abstract vs. concrete messages, which may subsequently influence attitudes toward the company and purchase intention (Kim et al. 2010; Lin et al. 2011; Stanaland et al. 2011; Tian et al. 2011).
In addition to the PA/plasmin system, tPA interacts with other effectors such as low-density lipoprotein receptor-related protein (LRP) [60], [61] and latent platelet-derived growth factor-CC (PDGF-CC) [62], [63] which may subsequently influence the brain ECM remodeling and neurite outgrowth.
Dermcidin may subsequently influence survival via two or more mechanisms.
Furthermore, extracellular vesicles containing histone H1° may subsequently influence recipient cells in the cancer microenvironment.
Sex steroids can also modulate the inflammatory response and may subsequently influence outcome after septic challenge [ 30].
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However, models seeking to explain how individual difference and structural level variables may influence each other and subsequently influence acculturation and adaptation are needed.
Finally, it is possible that smoking may lead to epigenetic alterations that subsequently influence natural history of disease [ 47].
Therefore, increases of CGA expression in spring vs. autumn may increase the synthesis of TSH, and subsequently influence in situ production of T3 by affecting DIO2 in the ME [26] (Fig. 6).
Also when this information is provide by health care providers it may influence the care they provide, and subsequently influence concordance with the guideline.
Characterization of multiple chemical exposures is necessary to understand the impact of the environment on disease, given that a combination of several low level exposures may contribute to a larger xenobiotic body burden and subsequently influence disease incidence [ 48, 49].
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