Due to the relatively low concentrations of the compounds used in our experiments, we may have mainly identified agents that strongly induce PLD.
We have recently shown that the taxanes also strongly induce TNF alpha production, which may also promote apoptosis through binding to its receptor TNFR1 [ 9].
In addition, cancer therapies strongly induce apoptosis in the tumor tissue already at an early treatment stage and thus may be monitored effectively using apoptosis-specific molecular imaging probes [24].
Ixabepilone is not a good substrate for MDR and does not strongly induce P-gp expression (possibly because of the relatively flexible structure of this compound), which may in part account for its activity in drug-resistant tumors [ 11].
We have previously demonstrated that butyrates strongly induce in vitro growth inhibition and apoptosis in different human prostate cancer cell lines (Maier et al, 2000).
This fact suggests that structural disordering associated with the decrease in crystallinity may be most strongly induced at this mm fraction.
This may be why drought stress strongly induced the expression of these 21 nt sRNAs; most conserved miRNAs belong to this group.
As the PDRs were also strongly induced (Table 5), it may be possible that the ABC transporters were involved in pumping out the citrinin-glutathione complex.
The protein is a functional component of the AP-1 complex, and is strongly induced by UV-irradiation and may be involved in ML-1 cell apoptosis (Li et al, 2002).
