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It is tempting to speculate that these dietary components may stimulate mitochondrial biogenesis through ATM to maintain functional mitochondria and regulate ROS.
Misfolded proteins bind chaperones that consume ATP and may stimulate mitochondrial oxidative phosphorylation to generate ROS as a byproduct.
It is therefore difficult to ignore the possibility that n-3 PUFAs may stimulate mitochondrial biogenesis without changing mitochondrial abundance (i.e., increased turnover of the organelle).
There is growing interest in the influence of n-3 PUFAs on mitochondrial biology following early reports that n-3 PUFAs may stimulate mitochondrial biogenesis.
Taken together, these studies provide promising early evidence that n-3 PUFAs may stimulate mitochondrial biogenesis, but no studies have been conducted to determine whether dietary n-3 PUFAs can prevent or reverse impairments in muscle mitochondrial content or function in the context of aging.
An argument supporting this increase in 'energy-efficient metabolism in astrocytes' is that inflammatory reactions in astrocytes in response to infection or other stressors are metabolically expensive events (Johnson et al., 2012) and may stimulate mitochondrial metabolism for the energy support.
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Although cold exposure and exercise may each stimulate mitochondrial flux and capacity, it is not clear whether the two act independently [6] [8], [10], [12].
The increase in UCP3 may stimulate higher mitochondrial uncoupling and further energy demand/supply disparities.
As mitochondria descend from a bacterial endosymbiont, the identification and application of a similar protein that can specifically stimulate mitochondrial activity may well yield beneficial results.
In the current study, higher ADP at sea level may have stimulated mitochondrial respiration and thus ATP production (29).
These findings raise the intriguing possibility that strategies to stimulate mitochondrial activity during aging may delay the onset of pathology and extend healthspan.
More suggestions(15)
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may disrupt mitochondrial
may stimulate careful
may inherit mitochondrial
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