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Although no constituents could be linked to the immunomodulatory properties of the plant at this stage, studies have shown that different types of flavonoids may stimulate human peripheral blood leukocyte proliferation [ 39, 40].
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It is not clear whether iGb3 is also a self antigen for human NKT cells since humans lack the enzyme required to synthesize this compound [22], however it seems likely that the self antigens that stimulate human NKT cells may also be minor components of the pool of cellular ligands presented by human CD1d molecules.
Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension.
Toll-like receptors stimulate human neutrophil function.
Mouse VEGF can also stimulate human HUVAC cell proliferation [41].
These cytokines may stimulate leptin secretion from human adipose tissue as well as hepatic CRP synthesis [ 34, 35].
On the one hand, Porphyromonas gingivalis causing periodontitis has a functional PAD enzyme, which is quite similar to human PADs, and subsequently the infection may stimulate antibody production against the human PADs as well [ 88].
Administration of recombinant human erythropoietin may stimulate erythropoiesis, increase hematocrit levels and hemoglobin concentration, and reduce the need for RBC transfusions.
However, the high similarity with self does contribute to concern that epitope cross-reactivity with a human homolog may stimulate autoreactive T cells to break tolerance and lead to autoimmunity.
Hepatocyte growth factor (HGF) is a potent hepatocyte mitogen and may stimulate the proliferation and invasiveness of human hepatocellular carcinoma (HCC) cells through the c-met receptor.
Further epidemiologic studies into this phenomenon are required, but the idea that mycoplasmas can exacerbate, or perhaps even initiate human prostate malignancy may stimulate new thinking on how we prevent, diagnose and treat prostate cancers.
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