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In an effort to identify extracts that may stimulate glucose uptake, similar to insulin, a high throughput-screening assay for measuring glucose uptake in skeletal muscle cells was established.
These data suggested that AE may stimulate glucose uptake in skeletal muscles through activation of the Akt/GLUT4 pathway.
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Furthermore, the enhanced AMKP activation may stimulate muscle glucose uptake, this occurs through a distinct mechanism than the insulin-signaling pathway [ 34].
In other studies, H2O2 concentrations below ∼1 mM do not seem to stimulate glucose uptake[31], [32], but may inhibit insulin-stimulated glucose uptake[31], while higher H2O2 concentrations increase glucose uptake in various muscle model-systems[9], [11].
Insulin-independent pathways to stimulate glucose uptake and GLUT4 translocation may offer alternative therapeutic avenues for the treatment of diabetes.
Therefore, this AS160 protein may link the pathways via which exercise and insulin stimulate glucose uptake.
These could stimulate glucose uptake in differentiated skeletal muscle cells.
FGF-21 has been shown to stimulate glucose uptake in adipocytes and suppress hepatic glucose production [23].
These data together with parallel increases between fructose intake and obesity development [ 13] have led to the 'fructose hypothesis' which postulates that fructose, compared to glucose, may stimulate food-seeking behaviour, food intake, and body weight gain.
In mammals, high levels of glucose may stimulate AKT-dependent growth signaling, induce DNA damage, an increase in superoxide level and senescence (Sheu et al. 2004; Ksiazek et al. 2008; Yokoi et al. 2006; Lee and Han 2009).
The leaves extract of MM decreased the serum glucose level and increased pancreatic insulin as shown in our research exertion Therefore result suggests that MM leaves extract may stimulate insulin secretion and decreased serum glucose.
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