Sharply pointing fibers are discussed to stimulate chronic inflammatory processes [ 4].
Anti-inflammatory medications may be beneficial in treating fibrosis, because inflammatory mediators may stimulate HSC activation in chronic liver diseases such as viral or autoimmune hepatitis and drug-induced liver injury.
Long-term chronic inflammation may stimulate synovial cell hyperplasia and neovascularization in the OA patients [ 23, 24].
Overproduction of NO by chronic alcohol exposure may stimulate the synthesis of some cytokines, such as interleukin-1 (IL-1), IL-2, IL-6, IL-8, and TNF- α, which in turn stimulate the synthesis of NO [ 28].
In their review paper, Horan and colleagues propose that the trauma, stress and fear associated with CSA may stimulate enhanced CRH gene expression and chronic overproduction of CRH in the brain, making a woman susceptible to elevated placental CRH gene expression during pregnancy and consequently, increased risk of PTB [ 51].
It is plausible that hyperglycemia resulting from IFG may raise the risk of periodontal disease but also that chronic systemic inflammation from periodontal disease may stimulate inflammatory cytokines (C-reactive protein, tumor necrosis factor α, and interleukin-6), leading to insulin resistance and hyperglycemia (22).
The authors assert that consuming milk containing the beta-CM-7 protein may stimulate phlegm in the respiratory tract, particularly in people with chronic lung conditions.
Enhanced ER PM contact formation may stimulate STIM2-dependent activation of Ca2+-channels, which could lead to chronic Ca2+ overload and finally to necrosis and cell death through apoptosis [ 39].
This would suggest that TWEAK-Fn14 signalling may stimulate osteoclastogenesis and hence could contribute to the bone loss associated with chronic inflammatory diseases [ 10, 11].
We can live without extremists, however much they may stimulate our faculties of lust and rage.
