If we aim at discovering the mechanism producing gene clustering, not its subsequent association with other events, the underlying causality is not as straightforward as it may seem: if functional coupling could stabilize clustering, clusters need to exist in the first place.
These findings reveal the crucial role for LecB in the formation of E-Cadherin clusters, which may stabilize β-Catenin firmly within these complexes and thereby prevent the nuclear translocation and the target gene expression.
Together, these findings suggest that Zeb1-mediated EMT, through mir-23a cluster regulation of Nedd4L protein levels, may stabilize or enhance the activity of TGF-β signaling and thus contribute to disease persistence.
"The White House is saying it's going to stabilize," the former senior Administration official said, "but it may stabilize the wrong way".
Only when this cluster is a full four electrons short does it rip them from two water molecules, producing the waste product oxygen (O2); the calcium ion may stabilize the first oxygen molecule until the second one is added.
At some point, env diversity may stabilize or even decrease.
AvrA may stabilize TJ structure by dampening the inflammatory response.
Nonmalignant stenoses may stabilize over time as the tissue stiffens.
Alternatively, CXCL10 and CXCL11 may stabilize distinct receptor conformations.
We hypothesized that active transcription may stabilize the holocomplex.
