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Alternatively, we cannot exclude the possibility that scFv-6E may stabilize a recently described oligomeric species having fibrillar features [16], although the existence of such oligomers has yet to be correlated with cytopathology.
Our result suggests that Fam20A binds ATP, which may stabilize a conformational state that is required for the allosteric function.
We speculate that binding to ATP may stabilize a conformational state of Fam20A that is preferred for the allosteric activation of Fam20C.
This Arg residue may stabilize a coordinate bond between the zinc ion and Cys residues, which are the crucial components of ZnF1.
Moreover, auxilin may stabilize a first intermediate, in which the free energy of auxilin binding compensates for some of the distortion required ultimately to disassemble the lattice.
Although a given detergent may stabilize a membrane protein, it does not mean that the detergent is the best candidate for the preparation of proteoliposome samples, as exemplified here with Rv1861.
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Arginine, by gluing the C lobe of each subunit to the inter-dimeric junction, may stabilize an enlarged active centre conformation, hampering catalysis.
Policymakers and legislators need to recognize that although military intervention and counter-terrorism efforts may stabilize an area for a brief period of time, they often enrage local populations and spur recruitment.
Alternatively, Eco1-mediated acetylation may stabilize an intermediate state of cohesin in a way that makes subsequent cycles of ATP hydrolysis unable to alter the tethering conformation.
RGS proteins may stabilize an active GPCR/G protein/channel complex to limit the diffusion time necessary for activation and deactivation [ 11, 12].
These data suggested that DNA may stabilize an otherwise transient structural state of this IDR domain that then becomes susceptible to targeted binding by the tin compound.
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