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Since GPRC5C seems to be relatively ubiquitously expressed, coexpression of GPRC5B, GPRC5A, and GPRC5D may specifically increase the gene dosage in some tissues.
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HU modulates proteolysis related genes suggesting that pericellular proteolysis may be specifically increased.
DOI: http://dx.doi.org/10.7554/eLife.05116.009 The DNA content increases in sporadic AD neurons raised the question of what genomic loci may be specifically increased in AD.
Although cleaved caspase-3 was not detected in the non-infarct myocardium, significant increases in the infarct area confirmed the presence of apoptotic cells and suggest that Brn-3b(l) may be specifically increased in injured myocardium.
Given that specific IgG4-positive plasma/B-cell clones seem to play a central role in the pathogenesis of IAC, 24 we hypothesized that IgG4 may be specifically increased in IAC, whereas a nonspecific increase in IgG of different IgG subclasses could be expected in other immune-mediated disorders, such as PSC.
BMP8B may offer a mechanism to specifically increase energy dissipation by BAT.
However, HIF-2α may increase the inflammatory response, and therefore, optimal HIF-based therapies would be pharmacological agents that can specifically increase HIF-1α.
Another possible explanation for the current results might be that people suffering from tinnitus may only have specifically increased interoception for internal acoustic processes which would not be detected through the measures used in the study at hand.
Cell damage may also non-specifically increase eATP levels by allowing leakage from injured cells.
The patient's self-report of a return to full 'normal' activities was associated with improved functional recovery, and therefore a focus on activity normalisation, rather than specifically increasing activity, may offer the best opportunity for success in improving patient outcomes.
These results suggest the LTS criteria may not be useful for cities looking to prioritize infrastructure improvements for specifically increasing commuter cycling.
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