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Exact(5)
Accumulating evidence suggests that PDK1 plays a specific and distinct role from the canonical PI3K/Akt pathway, and that PDK1 may specifically activate signal propagation in tumor progression, as well as in cell migration and invasion.
SLAMF7 may specifically activate NK cell function, while inhibiting B and T cells [ 35].
Although avian cytokines have been poorly defined, they have the potential to control infectious diseases and can act as vaccine adjuvants that may specifically activate immune systems leading to effective protection [ 9].
Our results suggest that improvement of cognitive performance on insulin may be related to regional perfusion and vasodilatation and may specifically activate anterior regions that regulate attention-related task performance.
Since phosphorylation of the Pol II CTD occurs during transcription activation and marks Pol II engagement in the transcriptional process, the above results altogether suggest that NM1 may specifically activate transcription by maintaining Pol II in complex with actin at the gene promoter.
Similar(55)
Therefore, there is a true need for the development of additional anti-destructive drugs such as selective MMP-13 inhibitors that may target specifically activated synovial fibroblasts.
It is also likely that phosphatases may be specifically activated by estrogens, although this mechanism is still largely undefined (Fujita et al. 2010; Zivadinovic and Watson 2005), or other receptors might contribute.
The impact of sustained CXCR4 and CXCR7 activation on the desensitization and recycling of those receptors has yet to be explored, but may provide novel avenues with which we can specifically activate or de-activate chemokine receptors in human disease.
Thus, more effective chemotherapeutic reagents against cancers may be generated by development of compounds that specifically activate CREB3L1.
Chemicals that specifically activate PPARγ and up-regulate expression may promote the development of obesity.
Alternatively, prodrugs may be designed which are specifically activated by metabolic conversion in the parasite [ 10].
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