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Hence, it is possible that the HT may sort proteins into clefts before these structures are exported from the parasite to the erythrocyte.
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Additional signals may be required to sort proteins to the various compartments of the endocytic system or to retain them in secretory compartments.
Notably, mutation in ζ subunit also causes HSP disease [ 77], indicating AP-4 and AP-5 may sort the same cargo proteins or both important for axonal maintenance [ 78].
Individuals who sorted in because of the unique design may sort themselves out with the change.
Filter-based isolation requires sorting proteins and EVs.
Alternatively, the HT motif may also sort soluble and membrane proteins from the lumen of the PVM to the lumen of clefts that assemble at this vacuole.
It also has accuracy limitations: two 500-residue proteins may be sorted differently due to a 5-residue motif.
The gene CCDC91 in this locus may affect protein sorting and membrane trafficking through interacting with GGAs (Golgi-localized, Gamma ear-containing, ARF-binding proteins) [22].
Thus, proteins present in early endosomal vacuoles may be sorted to at least three types of specialized sorting domains: tubular sorting endosomes, ETC or the bilayered coat.
Detection in some genomes, but not others, may reveal sorting system components by comparison of the phylogenetic profile of the class of sorting signal to that of various protein families.
Lawyers may have to sort it out.
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