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Several explanations exist for why a strict diet, low in calories but high in nutrients, may slow aging.
Researchers have increased life-spans in yeast and mice by having them consume fewer calories per day, and ongoing studies suggest that a strict low-calorie diet may slow aging in primates, too.
Several approaches in combination with drugs and diet may slow aging, although not making it negligible [ 115].
Interventions that target the gate-keeping tumor suppressor pathways may slow aging at the cost of cancer or vice versa.
This study also provides evidence that the effects of MR are not only secondary to its effects on reducing growth and development and that in fully developed and grown mice, it may slow aging.
Re "Tests Begin on Drugs That May Slow Aging" (Aug. 18): I asked my doctor if eating a severely calorie-restricted diet would make me live longer.
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In contrast to the gate-keeping tumor suppressors, care-taking tumor suppressors maintain the stability of the genome and may simultaneously slow aging and prevent cancer.
All rely on molecular changes linked to aging, but must still overcome confounding factors such as individual variation and disease, which may speed or slow aging.
We also identified unique amino acid changes and rapidly evolving genes in the bowhead whale that may contribute to slow aging in this species.
Resveratrol is thought to slow aging by mechanisms that may be related to caloric restriction.
Still, there's hope that van Deursen's group may have identified a new drug target to slow aging.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com