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An emerging disease-modifying approach to face the multifactorial nature of AD may be represented by the development of Multi-Target Directed Ligands (MTDLs), i.e., single compounds which may simultaneously modulate different targets involved in the neurodegenerative AD cascade.
Xenobiotic-metabolizing genes may simultaneously modulate this disease risk.
Furthermore, rhAPC may simultaneously modulate the inflammatory response.
Furthermore, it may simultaneously modulate the inflammatory response.
Our results suggest that DNA-repair pathways may simultaneously modulate the risk of colorectal cancer for the Taiwanese population, and, particularly for rectal cancer and younger patients.
Hence, for instance, a local change in the NAD+/NADH concentration and/or the ratio of the redox status, perhaps just restricted to certain nuclear loci where histone transcription (and/or DNA replication) initiates, may simultaneously modulate histone transcription, DNA replication and other S-phase events.
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Inhibitors of HSP90 have been developed that can simultaneously modulate several intracellular regulatory pathways [ 77].
Consequently, a GAPDN pathway was designed and implemented experimentally to simultaneously modulate the NADH and NADPH generation.
However, simultaneously modulating multiple genes on the chromosome remains challenging in prokaryotic organisms, including the industrial workhorse - Escherichia coli.
Our results indicate that thrust forces and power dissipation can be simultaneously modulated via the shape-morphing strategy.
It is likely that B2 receptors activate a single intracellular pathway (PLC/Ca2+/InsP3/calmodulin) which, in turn, simultaneously modulates the two components.
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