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With respect to signaling pathways potentially involved, activation of the Gq-coupled melanopsin may signal through DAG-mediated PKC activation that is known to regulate adipocyte lipid metabolism34 and increase lipolysis35,36.
Or in the case of someone who is no longer able to speak, I do not stop to notice the subtle clues that he may signal through his body language or emotional vibes.
A possible explanation could be that PLN induces endogenous ligands which may signal through TLR2 (and/or TLR4) [40], [40].
The ability of DOP-3 to selectively modulate the octanol avoidance responses of rgs-3 animals suggests that endogenous DA may signal through DOP-3 to regulate octanol sensitivity in wild-type animals.
However, induction of C. elegans DR by limiting the amount of bacteria on plates suggests a lifespan-extending mechanism that is DAF-16-dependent [34], indicating that distinct food deprivation regimens may signal through different pathways to impact lifespan.
So far, there is a single connecting report that TGF-β also may signal through CEAR.
Similar(38)
This implies that the set of MYC targets downstream of ANGPTL2 and NOTCH signaling is highly similar, supporting our hypothesis that ANGPTL may signal partially through NOTCH.
The HER3 protein, which has no kinase activity, may signal in the nucleus through several C-terminal transactivation domains [ 17].
Note that the striatum may signal the cortex not only through cortico-basal ganglia loops.
These proteins may directly signal through prostate epithelial surface receptors, or may also signal through crosstalk to the androgen pathway, which is central to prostate carcinogenesis (Culig et al, 1994).
BMPs may also signal through SMAD-independent pathways via mitogen-activated protein kinases (ERK, p38MAPKs, JNK).
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CEO of Professional Science Editing for Scientists @ prosciediting.com