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This paper is concerned with examining simple measures of laterality and hand control including measures of motor function, which may signal developmental deficits relevant to scholastic ability.
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To elucidate the molecular basis for c-di-GMP recognition and binding by the BldD CTD and to gain insight into how this interaction may elicit developmental signaling, we determined structures of the S. venezuelae BldD CTD (residues 80 166) and S. coelicolor BldD CTD (residues 80 167) in complex with c-di-GMP.
All these observations point to multiple and complex control of CXCL12/CXCR4 signaling which may have developmental stage- or tissue-specific elements.
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