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Although Hrk1 is most homologous to Srk1, the closest C. neoformans homolog to Cmk2, Rck1, and Rck2 is also Hrk1, indicating that Hrk1 may share functions with either of the MAPKAPKs.
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Evidence suggests that Id4 may share some functions with its family members but emerging data support the role of Id4 as a tumor-suppressive.
Doa10 is an ER membrane protein, and may share some functions with Hrd1, the other major ER ubiquitin ligase.
However, gene set enrichment algorithms are designed to pull out lower level expression level changes coordinated across genes that may share common functions.
EHDs may share redundant functions in mammalians, as EHD1 knock-out mice have only a mild attenuated re-cycling phenotype [26].
We obtained an AuC of ∼0.8 (Figure S3A), indicating that the proteins indentified in the IP experiments are related to dysferlin in MedLine abstracts, and may share similar functions and/or pathways.
These similarities suggest that the proteins may share biochemical functions.
The members of subfamilies may share conserved functions not shared by other species.
Conceptually, gene families have a common ancestor, arise by gene duplication, and may share similar functions.
Genes within a clan likely diverged from a common ancestor gene [ 8] and may share common functions [ 9].
Although they may share similar functions, each has its own characteristics and limitations, leaving rooms for further improvement.
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