Suggestions(5)
Exact(6)
Considering that two different GO terms may share functional similarity, we also calculated the average similarity score between the best prediction and the real GO terms (Table 2), using the tool G-SESAME [39], which defines the semantic similarity between two GO terms as the percentage of their common sub-graphs starting from the root of the GO "directed acyclic graph" (DAG) [39].
GO term comparison is a yes-or-no binary criterion in this study even though two different GO terms may share functional similarity.
There is evidence that miRNAs are often clustered and sometimes co-expressed from the same primary transcript, leading to the hypothesis that they may share functional relationships [ 26].
Importantly, ROS are important mediators of lysosomal cathepsin release during necrosis, suggesting that it may share functional similarities with NE release during NETosis.
Together these findings further strengthen the notion that the AtMDL proteins are bona fide co-orthologs of HsMIF and HsDDT that may share functional conservation with respect to core biochemical activities of this protein class.
Clearly, understanding the function and regulation of TBX2 in RMS will be important in interpreting the many known modifications in RMS including enhanced FGF signalling that may be an activator of TBX2, and the roles of pRB and the Myc family, which may share functional interactions with TBX2.
Similar(54)
This indicates that PBEC and KC not only share structural characteristics, but may also share functional characteristics.
Interestingly, Zc3h12 family was clustered into same group with Zfp36 family and Rc3h family, suggesting that they may share similar functional features.
miRNA genes are sometimes observed as clusters frequently transcribed as single polycistronic transcript [2], [10], implying that they may share common functional relationships.
Therefore, they may share some functional similarities.
We also suggest that homologous KCTD members may share similar functional roles in proliferation, transcription, protein degradation, regulation of G-protein coupled receptors and other molecular or biological processes.
More suggestions(15)
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