We have learned that some mutations may sensitize the effects of a drug, while others may negate it.
The significance of chemosensitive primary sensory neurons in headache mechanisms is further supported by the observation that some pathophysiological events may sensitize meningeal sensory nerves [11].
Finally, the authors show some data suggesting that SPOP mutations may sensitize cells to PARP inhibitors, which have been shown to be synthetic lethal with BRCA1 mutations.
For example, recently we have found that prior irradiation, a known initiator of meningioma formation, may sensitize leptomeningeal cells to the mitogenic effects of cerebrospinal fluid in some scenarios [ 39].
The downregulation of this pathway is associated with increased sensitivity of chemoresistant cells [ 44], and hence α-mangostin may sensitize the colon cancer cells to the apoptotic effect of chemotherapeutics.
Its tree-dappled plain and far-off mountains may sensitize you to a similiarly exquisite vista tucked in a corner of Maxfield Parrish's otherwise sappy "Saint Valentine," which hangs nearby.
Thus, the strategies for targeting these pathways may sensitize cancer cells to gemcitabine treatment.
Activation of pro-inflammatory pathways may sensitize microglial cells to promote hypoxia-induced injury of the developing brain.
It is fundamental to assess whether a preexisting injury may sensitize lungs to the deleterious effects of mechanical ventilation.
A "feeling for the [individual] organism" may sensitize a scientist to critical data (Keller 1983, Ruetsche 2004).
