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This strategy consisted of preparing membrane-impermeant inhibitors that may selectively target the tumor-associated hCA IX.
This is the first report of inhibitors that may selectively target CA IX, due to their membrane-impermeability and high affinity for this clinically relevant isozyme.
A further complicating factor is the strategic nature of an attacker, who may selectively target users offering the best value in terms of likelihood of success and resulting access privileges.
Studies in males suggest that alcohol concentrations relevant to the beginning stages of binge intoxication may selectively target tonic GABAergic inhibition mediated by GABAA receptor subtypes expressing the δ-subunit protein (δ-GABAARs).
Fuel wood extraction may selectively target individual trees and only degrade forests.
A small subset of T cells (gamma-delta T cells) is able to recognize phosphoantigens that are overexpressed in some cancer cells and may selectively target and kill cancer cells with high levels of phosphoantigen.
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Inhibiting proteins involved in the G2/M checkpoint, such as Wee1, may therefore selectively target cancer cells whilst sparing normal cells with a functional G1/S checkpoint.
Tumour vasculature is a new promising target for targeted anticancer therapies; tumour vasculature may be selectively targeted by 'vascular disruptive' agents, which cause rapid blood vessel shutdown (within minutes with subsequent tumour necrosis), or the development and subsequent stabilisation of tumour vasculature may be inhibited by 'antiangiogenic agents' (Tozer et al, 2002).
Depth-resolved capability provides important evaluation of the deep retinal capillary plexus that may be selectively targeted in retinal vascular or inflammatory disease.
In addition, we identified characteristics, e.g. high m-CCI score and hemodialysis among ESRD patients that may be selectively targeted for interventions to further reduce the risk of SAB.
Given that IDRs are highly sensitive to their local molecular environment (Uversky, 2013), it is possible that the TAF2 IDR may be selectively targeted by some cellular factors to modulate transcription initiation in a manner analogous to the action of the tin-based inhibitor described here.
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may selectively accumulate
may selectively alter
may selectively promote
may selectively function
may selectively eat
may selectively act
may selectively occur
may selectively release
may selectively recruit
may selectively disable
may selectively lose
may selectively interact
may selectively affect
may selectively choose
may selectively cite
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