Sentence examples for may restrict cell from inspiring English sources

These results propose that miR203 may restrict cell motility, a hallmark of EMT.

The overexpression of miR-15b may restrict cell proliferation and increase the rate of cellular apoptosis, and abundant expression may indicate a low risk of HCC recurrence [ 36].

In addition, to ensuring correct progression through the cell cycle, there are internal checkpoints that monitor the conditions to generate healthy daughter cells, and cell damage or stress may restrict cell cycle progression and/or induce cell death, through them.

The under-phosphorylated form of Rb is present after Antp-p21 treatment, suggesting that Antp-p21-treated cells lost their ability to phosphorylate newly synthesized Rb at multiple sites and that under-phosphorylated Rb may restrict cell proliferation (Additional file 1: Figure S4).

This observation suggests that downregulation of miR-181a in old muscle tissues may restrict satellite cell proliferation and thus reduce the ability to replace damaged muscle.Thus, we propose that downregulation of miR-181a may be related to increased inflammation in the elderly.

Estradiol secretion by the ovarian tissue is reduced in vitro after being exposed to oncotherapy and also if collected from aged ovaries [ 77] indirectly indicating a compromised somatic environment which may restrict stem cells to undergo follicular assembly and thus result in menopause.

In addition, these L50 tumours showed over-expression of collagen IV, and reduced laminin 332, VEGF and CD34 levels, which may have restricted cell adhesion and neoangiogenesis.

At the end of the experiment, tumours were recovered and marker proteins were analyzed by western blotting, RT-PCR and immunohistochemistry. L50 tumours grew more slowly, showed a strong decrease in cyclin B1, over-expressed collagen IV, and had reduced laminin 332, VEGF and CD34 levels, which, collectively, may have restricted cell division, cell adhesion and neoangiogenesis.

Indeed, MSC cultured under normoxic conditions exhibit premature senescence and a reduction in population doublings in comparison to cells cultured under hypoxia [ 81, 82] and may also show restricted cell division due to telomere shortening and replicative senescence [ 80, 83].

Although endothelial cell colony-forming units (CFUs) are widely accepted as an estimate of EPC number and function in cell culture, some important limitations may restrict the assumption that endothelial cell CFUs accurately reflect EPC numbers.

Emerging studies imply that the epigenetic memory of specific donor cell types may restrict the subsequent differentiation potential of derived iPS cells (46– 46).