Sentence examples for may restore sensitivity from inspiring English sources

Combination therapy with EGFR and MEK inhibitors may restore sensitivity to EGFR-TKIs.

Sensitising HB cells to apoptosis may restore sensitivity of resistant HB to established therapeutic regimens.

Therefore, agents that inhibit the PI3K/Akt/mTOR pathway may restore sensitivity to trastuzumab-based therapy.

Therefore, GSCs represent a unique model to investigate whether PARPi may restore sensitivity to TMZ or may be effective as monotherapy in PTEN-deficient GBM.

Finally, we tested whether activation of the PKR/PP2A signaling axis may restore sensitivity to chemotherapy of mice xenografted with cells that have reduced PKR expression.

This suggests that reactivation of the PKR/PP2A pathway in leukemic cells displaying reduced PKR may restore sensitivity to antileukemic treatment.

In vivo studies for multiple solid tumors have demonstrated that Src activity is implicated in resistance to chemotherapy and that inhibition of Src may restore sensitivity to chemotherapy [ 14– 16].

Evidence from in vitro and in vivo studies indicates that NOXA deficiency or MCL1 over-expression may protect cells from apoptosis in a p53- dependent or independent manner, whereas NOXA accumulation and MCL1 inhibition/degradation may help restore sensitivity to apoptosis [ 7- 9].