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Predicting the functional outcome of RNA editing remains a challenge, and may require thorough bioinformatics algorithms that cross-compare both sequence and quantitative information on all constituents of the transcriptome derived from the same samples.
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Nonetheless, it is also possible that the payment structure for children undergoing NIH care in Taiwan may require a thorough review because there is a unreasonably low payment schedule for children.
Overall, these findings indicate that short-form depression questionnaires are an acceptable substitute for clinical interviews in a setting where depression would not be routinely assessed, and would provide evidence that a patient may require more thorough assessment.
For real-time field applications, low-cost embedded computers with limited calculation and data recording capacity may be used; however, they require thorough study of the influence of variables involved in the algorithms for calculation of the damage indices, with ulterior optimization and required data reduction.
This knowledge is essential to compare the trajectories of those who have received a new therapy in addition to ChEI with those of patients treated only with ChEI, especially since therapies that may modify disease progression in AD require thorough long-term evaluation.
The repeated dose studies may give valuable input for risk assessment but require thorough evaluation.
Currently, the diagnostic approach to suspected AAD relies on imaging techniques such as computed tomography (CT) scan and transesophageal echocardiography, which nonetheless require thorough pretest clinical selection and may not be immediately available in all EDs [ 2].
Such combined effects may, however, make it difficult to demonstrate the relative benefits of targeting each pathway and the possibility of additive toxicity will require thorough evaluation.
Liquid samples, even gases, require thorough blending.
Whether or not this deal goes through, these issues require thorough investigation and consideration.
However, there are additional questions that require thorough elucidation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com