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Although heuristic approaches are very effective at exploring the search space, they may require relatively long time to find the global optimum solution.
For example, households may require relatively high rates of return for energy efficiency investments, which leads to lower investments in real markets than those levels predicted by models.
Although a study may require relatively few surgeons for adequate recruitment, if no surgeon displays individual equipoise, trial recruitment is unlikely to be possible.
On the other hand, genes involved in metabolism, which showed low promoter conservation, may require relatively less regulatory information in their promoter sequences.
A highly focused, single objective study may require relatively few instruments while a broad-based, multi-faceted study will require numerous measures.
However, we failed to detect any significant decrease in ERK phosphorylation, JNK phosphorylation and p38 kinase phosphorylation, suggesting that the maintenance of those pathways may require relatively low levels of Nox4 activity in HUVECs.
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The reason is that successful deterrence may require a relatively high probability of sanctions and thus a relatively high enforcement expense.
But the world economy may require only relatively few such clusters, in which case they cannot be distributed equitably over the globe.Furthermore, there are separate cultures even in a "frictionless" world (unless cultural uniformity is also loaded into the idea).
The finding, reported in today's Nature, suggests that although fig trees may require a relatively large area to reproduce successfully, they also may be better than other trees at coping with isolation or habitat fragmentation.
That is, untrained subjects, older individuals, or patients with chronic heart failure, for example, may require a relatively greater time to achieve V̇O2max compared to healthy, active, or trained subjects.
Although those patients who have displayed favorable facial growth may require only relatively routine orthodontic treatment, patients with unfavorable facial growth often need orthognathic surgery for complete correction of dentofacial discrepancies [11].
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