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Some patients, however, have a more chronic-relapsing course and may require low doses of glucocorticosteroids for several years.

In order to satisfy the constraints of high availability and high site resilience, multiple mirror-infrastructures can be provisioned in different geographical locations (location constraints); however, the performance constraints may require low network latency between different sites.

First, activation in the SOP may rely on high levels of proneural protein and low levels of NF-κB/Rel protein; conversely repression may require low levels of proneural and high levels of NF-κB/Rel protein.

Successful treatment of chronic pain with naltrexone may require low dosages.

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Clinical diagnostic or time-sensitive investigations may require low-throughput, 'on demand' sequencing and automated analysis — on benchtop or even portable sequencers — to deliver actionable results to clinicians.

However, we failed to detect any significant decrease in ERK phosphorylation, JNK phosphorylation and p38 kinase phosphorylation, suggesting that the maintenance of those pathways may require relatively low levels of Nox4 activity in HUVECs.

Thresholds for merging should depend on the sampling frequency, data quality, stimulus spacing, density of visual information, or even on the research question (e.g., studies investigating microsaccades may require very low thresholds).

High levels of EGF signaling at the distal region of the D. melanogaster leg disc are also initiated by Dll and are required for the development of the pretarsus and distal tarsus; more proximal regions may require a low level of EGF signaling (Campbell 2002; Galindo et al. 2002, 2005).

Taken together, we can postulate that the wild-type pol ι may require a low level of Mn2+ rather than Mg2+ as a metal for performing proper polymerase function for two reasons: (i) mediating efficient catalysis and (ii) facilitating tight DNA substrate binding, although the structural basis for such a scenario has not been revealed yet.

Similarly located structures less than 45 metres tall may require a low-intensity light.

Participants that may require constant low-level care that must be paid for out of pocket may be better off with a combination of Part D and medigap coverage, while healthy participants seeking lower premiums may prefer an advantage plan.

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