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Furthermore, obtaining a positive specimen may require invasive techniques.

Such patients may require invasive haemodynamic monitoring [ 1].

The EPTB diagnosis may require invasive procedures or supportive evidence from other modalities.

1 Patients with advanced COPD are often hospitalized for acute respiratory failure and may require invasive mechanical ventilation, which is associated with high inhospital mortality rates ranging from 6% to 24%.

Treatment that is directed primarily at treating the epilepsy depends on locating the epileptogenic zone and may require invasive electroencephalography (EEG) studies, as this area may not be the same, for example, as areas that show contrast enhancement, which are likely to be the priority for resection for primarily oncologic purposes.

If we assume that the proportion of patients who may require invasive ventilation or intubation in acute cardiogenic pulmonary oedema is 10%, then the sample size of this meta-analysis (n = 290) could only achieve a positive significant result if the relative risk reduction for requiring intubation is more than 80% when BiPAP is compared with CPAP.

Similar(54)

Although these symptoms are not unusual near the end of life, they may not require invasive treatment and they may not be alarming when understood and expected [ 59].

Using the SNP approach developed in this study, half of these at-risk couples may not require invasive prenatal diagnosis when the SNP with paternally-inherited wild-type allele is present or when the SNP with paternally-inherited mutant allele is absent in the fcDNA extracted from maternal plasma.

The DST may require more invasive procedures, but it is a well-validated prognostic measure in patients with a primary recurrent mood disorder.

As previously mentioned, even though with the combination of both techniques most lymph node stations within the mediastinum can be reached, stations 3, 5 and 6 are not accessible to either technique and may require more invasive staging.

Addressing these larger, more serious problems may be more painful and costly and may require more invasive interventions.

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