Sentence examples for may require intact from inspiring English sources

Consequently, clinically-relevant assessment of urodynamic function and dysfunction may require intact behavioral states and necessitates the development of urodynamic recording configurations where these aspects are integrated.

Therefore, certain biologic agents used in the clinic may require intact lipid rafts to exert their therapeutic function.

They may also require intact immune systems to develop properly (76).

Thus, Bmi-1i-mediated growth inhibition may not require intact p16INK4A/pRb checkpoint pathway, as it is also reflected in the absence of p16INK4A induction in the NHOK and SCC4 cells after Bmi-1 knockdown.

In such situations of circulatory irregularity, end-organ perfusion such as cerebral blood flow may require an intact autoregulation to ensure stable microcirculation.

However, a potential pitfall of this approach is that blocking telomerase may lead to the activation of alternative telomere maintenance (ALT) pathways or may require an intact p53 response.

We produced in the meantime an (LPS-free) Rv2958c protein which leads as well as to IL-17 production in blood from TB + individuals (our unpublished data), suggesting that IL-17 production may require the intact protein structure and subsequent cellular processing and presentation.

These assays suggest host impairments in DNA repair, but they have found limited application in the clinical setting because they require intact cells, are labour intensive and may have limitations with respect to reproducibility (Berwick and Vineis, 2000).

Further study that might require intact virus is essential.

Taken together, these findings suggest that TRN-mediated inhibition of thalamus is a robust driver of local slow wave activity, and that slow waves in the intact brain may require both cortical and TC neurons to fire in a coordinated rhythm.

While this result is not fully consistent with what we observed in vitro, the complexity of the in vivo intact mammary gland may require several influences (secreted factors, direct cell contact, stromal contributions, etc) to promote optimal growth of R2-T1AS tumors in the nude mouse xenograft model.