Where there is a lag in the response time of a measurement endpoint to a stressor due to inertia in the system, an accurate measurement of the effect of the novel management may require experiments running over several years.
This can be done essentially regardless of ambient illumination, although other factors, such as glare or reduced retinal illuminance, may require further experiments beyond the scope of this paper (c.f. Kline, 1994; Owsley et al., 1983; Sloane, Owsley, & Alvarez, 1988).
Probably, the establishment of optimal parameters (e.g., incubation time, PS concentration, media composition, and cell density) may require that experiments on PS uptake characteristics and dark toxicity are performed in parallel.
Although Constable et al. [ 11] and Melki et al. [ 12] have provided arguments toward basic contrast differences between conventional and fast spin echo sequences, the contrast loss for T1-weighted SE and FSE at higher fields has not been adequately explored and may require dedicated experiments similar to the ones proposed here and more.
This issue can be quickly and simply addressed by including some indication of the percentage of Foxp3 expression within the PD1+CXCR5+ population Tfh in Figures 1 and 7. Presumably the data in Figure 7 is already available and simply requires reanalysis while Figure 1 may require a further experiment.
When a potential catastrophe looms, formal scientific experiments may require too much time.
When a potential catastrophe looms, formal scientific experiments may require too much time or too many valuable resources.
While experiments may require decades until the desired information is available (Zenner et al. 2011) stand growth simulators can do this much faster, albeit perhaps with less certainty (von Gadow 1996).
Traditional biological and medical methods to study those genes may require expensive and laborious experiments.
We do anticipate that such studies may require hundreds of different experiments to identify the value of any given design parameter for improved protein production.
