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Therefore, modulation of CYP3A enzyme activity in smokers may require dose adjustment for some inhaled drugs.
These factors should be taken into account when starting an antidepressant and in some cases may require dose adjustment.
As tolvaptan is also primarily metabolized by the CYP3A4 pathway, coadministration of calcium channel blockers, macrolide antibiotics, or azole antifungals may require dose adjustments.
Although the renal clearance of NOACs vary, patients with renal impairment may require dose reduction to avoid increased plasma concentrations of NOACs [ 4, 90– 92].
Comparisons concerning the numbers of drugs that may require dose adjustments were done using the two-sided Friedman- or Wilcoxon-test, as appropriate.
The future strategies for therapy of malignancies in which both radiation and chemotherapy are employed may require dose modification or treatment planning to limit bone marrow toxicity.
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But to obtain enough of these estrogens to counter a severe case of hot flashes or night sweats may require doses that are as strong, or nearly so, as pharmaceutical estrogen products and may present comparable risks.
This data indicates that the potential beneficial effects of statins in EAU may require doses greater than those used in the routine treatment of hyperlipidemia in humans.
Patients taking ropinirole may require dosing adjustments with the introduction, withdrawal or dose adjustment in any of these medications.
Individual patients may require doses to be adjusted by more than a factor of 2 to achieve effective analgesia without adverse effects (See Table 2) [ 26].
Patients on warfarin may require doses ranging from less than 10 mg/week to over 100 mg/week in order to achieve the same level of therapeutic anticoagulation [ 2, 3].
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