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Channel opening may require disruption of this salt bridge network, presumably by the binding of ADP to the three basic residues located on these helices.
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Further statistical method development is expected to lead to substantial improvements in fine-mapping causal regulatory variants, and may illuminate novel mechanisms that do not necessarily require disruption of transcription factor binding [ 34].
Epithelial regulation of MAPK signaling in response to membrane disruption involves distinct pathways and may require different strategies for therapeutic interventions.
In a recent podcast on the agency's Web site, an announcer said cheerfully that weekend disruptions on 12 subway lines may require commuters "to ride backward just to go forward, or change your traveling pattern altogether".
As several forms of HIT may require significant upfront investments and may cause significant disruptions in clinicians' workflow at least initially, most IDNs have had to make choices about the types of HIT to adopt.
Some serious complications associated with vigorous coughing may require prompt assessment and treatment, e.g., cough-related syncope, cardiac arrhythmias, pneumothorax, splenic and venous ruptures, seizures, loss of consciousness, and disruption of surgical wounds and intravascular catheters [ 1].
That may require legislation.
Markets may require "adult supervision".
It may require thinning out.
The hernia may require surgery.
Cloning may require some horsepower.
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CEO of Professional Science Editing for Scientists @ prosciediting.com