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Our data suggest that a reduction in DCC expression may require dense methylation in the promoter CpGs and LOH of the 18q locus, according to the two-hit theory [ 33].
Thus, reduction of DCC expression may require dense CpG promoter methylation and LOH of the 18q locus according to the two-hit theory as a common behavior of tumor suppressor genes [ 33].
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Full resolution of relationships among basal eudicots may require denser sampling of both taxa and genes.
On the other hand, for cataract operations that may require a higher volume of irrigation solution or longer phacoemulsification time, such as dislocated lens, dense cataracts and inexperienced surgeons cases, BSS Plus may contribute to lower endothelial cell loss.
That may require legislation.
Cloning may require some horsepower.
Markets may require "adult supervision".
It may require thinning out.
The hernia may require surgery.
Upkeep may require historical expertise.
That may require 20 reactors.
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