Symptomatic treatment is recommended for mild irAEs, while management of more severe reactions may require delay or omission of a dose and intense monitoring.
The use of special laboratory techniques may be required, delaying the likelihood of detection in the absence of clinical suspicion.
In the setting of suspected or proven malaria, cross-sectional imaging with CT allows differentiation of the common splenic infarction from rupture, since the latter may require immediate or delayed splenectomy [11].
It may require additional delay but it doesn't necessarily ensure additional scrutiny," Obama spokesman Josh Earnest told reporters on Tuesday.
The cost of LBNE may require a delay in Fermilab's plans for another big project, a high-power proton accelerator called Project-X to replace the lab's current complex of accelerators.
Such confusion leaves room for interpretation that may require long delays and intensive court battles to resolve.
Further, fertility preservation options yield the best results when undertaken prior to cancer treatment but in some cases may require a delay in treatment.
However, a proximal humerus lesion may require further delay in metastasectomy to promote healing, whereas a chest wall primary, given the opportunity, may warrant metastasectomy at the time of definitive surgery, potentially leading to further variability in the management of the pulmonary nodules.
Bajardi et al. recently developed a similar large-scale geographic disease spread model, with which they showed that a vaccination campaign following the initial outbreak may require additional mitigation strategies to delay the epidemic [44].
These two markers, either alone or in combination, may be useful in early identification and targeting patients with diabetes who may require intervention to avoid or delay functional dependence.
