Where cancer cells cannot be eliminated with a single course of therapy, several steps may be required considering individual clones and subclones within the tumor.
However, there may be another, simpler explanation that requires considering the growth-promoting signaling pathways from an evolutionary perspective.
When field data become available they may require us to consider exposure-dependence of vaccine efficacy or intrinsic age dependence of the primary effect of the vaccine.
This may require to be considered in reviewing the methodology used in the PPS.
However, to exploit this approach may require the willingness to consider the possibility that drug targets might be addressed by molecules of rather low specificity and moderate potency.
However, design requirements of sophisticated structures such as satellites may require nonlinear behavior to be considered for better performance.
The techniques is applied to deterministic systems, and it is our belief that such system are important for modeling purposes, although analysis of extinction phenomena, such as tumor eradication, may require stochastic factors to be considered.
Thus a structure-based approach in which the effects of large numbers of amino acid changes on the active site are calculated may require the protein engineer to consider only the affinity of an enzyme for its substrate and product while ignoring the effects that temperature and solvent conditions may have on the enzyme.
From this, it is an obvious possibility that brain size may play a role in adaptation to urban life considering that this may require shifts in anti-predator behaviour [ 13], foraging behaviour [ 11], and nest site selection [ 17].
The latest financing gap may require Greece's European creditors to consider giving it debt relief and more money so that it can meet the requirements of its current 172 billion-euro bailout program, which came on top of a 110 billion-euro bailout program given in 2010, the I.M.F. said.
