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The main disadvantage of this technique is that it may require considerably longer time than the trocar technique.
Some MRI studies (e.g. breast MR, cardiac MR, MR spectroscopy) may require considerably more time than conventional single-level MR. Multidetector CT (MDCT) has largely replaced single-slice CT, thus increasing greatly the size of the average dataset to be reviewed for each CT study; this is compounded by the increasing use of multi-phasic CT studies for tissue characterisation.
Although it is possible to maintain a healthy diet within financial constraints, such diets may require considerably more time, motivation, planning, and knowledge than many patients have.
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The exact level of restriction required can vary considerably 50-822% of maintenance energy requirement at target weight) and overweight dogs with low energy requirements may require considerable caloric restriction [ 9].
Experiments to uncover the mechanistic basis of this association will require considerably more work, and we would like to leave readers with a sense of what may be possible and what our best leads are for future investigation.
These analyses require considerably much computation time.
Yet, the larger values for and require considerably more computation.
The CA models, utilizing local information, require considerably less computation.
OnyCap23 cell aggregates require considerably more mechanical manipulation to disperse into single cell suspensions than equivalent P4E6 aggregates indicating that cell-cell connections may be stronger within a sedimented OnyCap23 population; perhaps the "stickier" of the two cell lines.
Although high-sensitivity and data-rich toxicogenomic approaches may already be feasible for analyzing human responses to environmental stressors in some settings, applying these technologies to human populations exposed to low-level environmental contaminants will require considerably more development.
This epidemiologically directed short-term prophylaxis of close contacts may require antiviral stockpiles considerably larger than necessary for therapeutically treating patients, but our model suggests that this investment may still prove cost-saving, providing that the outbreak dissemination patterns and population attributes correlate with those assumed by Longini et al. (Appendix).
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