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Killing cancer cells through the oxidative stress may require compounds that generate ROS and, more appropriately, catalysts that convert the intracellular ROS into a cocktail of cytotoxic chemical species that selectively kills cancer cells.
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Because of solubility and volatility issues, however, many exceptionally high-and low-MW environmental compounds or highly lipophilic compounds may require new screening methods.
Delivery of transcriptional factors may affect genome stability, while small-molecule compounds may require more evaluations when applied in vivo.
As a result the interpretation of the site of action of these compounds may require re-analysis.
Biotrophic and endophytic fungi may require resistances to these compounds to maintain stable infections of plant hosts (Ambrose and Belanger 2012).
Nevertheless, the detection and measurement of these compounds may require extremely expensive and sophisticated techniques such as high pressure liquid chromatography, mass spectroscopy and nuclear magnetic resonance.
In turn, a given disorder may require treatment with several different compounds, as is commonly the case in epilepsy or asthma.
The MSSP was calculated using dry weight sugar basis, although the sugar syrup product contained 50%% water and other non-sugar compounds that may require further cleanup, at additional cost.
The optimization of compound properties may require some type of multiparameter optimization scheme in library design.
Screening a library of natural products will be rich in chemical diversity and may identify novel active compounds, but identifying the active compound(s) and subsequent targets may require extended fractionation procedures and biochemical techniques.
(Scratched silver may require white rouge or brown tripoli polishing compound instead.[14]).[14]
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