Therefore, their expression may require co-factors not present in ES cells.
Second, AR binding may require co-factors that are different in different cells.
Activation of some of these genes may require co-stimulatory signals that are lacking in the cell culture system.
Evaluation of Axl and PDGFR-α expression status may identify a subset of c-Met-positive bladder cancer patients who may require co-targeting therapy.
Apart from energetic economy, interacting gene products frequently need to assemble stoichiometrically or may require co-translation for forming a complex, which is promoted by co-expression.
In addition, the out-of-pocket expenses associated with some of these services may require co-payments for privately insured patients, but may be available at no cost to publically insured patients.
We also showed that MIR156 is involved in the regulation of TCL2, and SPLs may require co-activators to regulate the expression of their target genes, including TCL1, TRY, and possibly, TCL2.
This may suggest that TLR2-dependent activation may also require co-stimulatory function of CD40 for efficient S. aureus lipoproteins-induced signaling in macrophages.
Third, BCL2, BCL2A1, or BH4-domain peptides may require a co-factor for activity in vivo.
Second, BCL2 or BCL2A1 may require a co-factor for activity in vivo as has been described for the prototypic DAMP, HMGB1, which lacks significant activity in vitro when it is highly purified [23]-[25] [23]-[25]ires activity upon butding to other TLR ligacquires] or cytokines [24].
DES models have a time dimension as entities change state through time; have activities (e.g. consultations) that may require the co-operation of more than a single class of entity (e.g. between doctors and patients); and contain processes in the form of a chronological sequence of activities through which an entity must or may pass (e.g. patients pathways).
