These features may require alternative approaches in educational design in order to maximize learning for millennial students.
Critical illness may alter a patients PK behaviour [[2]] and therefore these patients may require alternative dosing regimens for optimal management [[3]].
Thus, tumors that do not depend on CDK4/6 for G1-S transition and/or can rescue CDK4/6 inhibition by the activity of other CDKs may require alternative approaches, including the use of compounds that affect cyclin D1 transcription or protein turnover and combination therapies that target multiple endpoints of cyclin D1 action simultaneously [50].
However, in light of the growing drug resistance to SP [37], [38], its continued use for IPTp may eventually be replaced by more effective alternative drugs which may require alternative dosing schedules.
In various conditions, including the host, the transcription of genes not controlled by PlcR despite the binding of the regulator to the PlcR box may require alternative sigma factors, such as σB, σH, or ECF factors.
Establishing function for some of these predicted transporters may require alternative genetic, biochemical, or physiological analyses.
65, 66 Patients refractory to steroid treatment may require alternative immunosuppressive therapies.
This also implies that there may be another indirect regulation of BCR-ABL on hTERT, which may require alternative pathways or through some other intermediate proteins.
These patients may require alternative approaches, such as early intensive chemotherapy followed by ASCT or participation in clinical trials of new molecular targeted agents.
However, insufficient response to PA with poorer prognosis and relapse rates of 30 40% after 5 10 years of follow-up may require alternative strategies.
