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Few causative factors have been identified: familiar forms are rare (about 1%); there is no clear genetic predisposition, and presumably tumorigenesis may require alterations in more than one gene.
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Therefore, formation of the bulgy shape in tadpoles may require alteration of the water permeability of the superficial epidermis of tadpole skin that might be achieved by expression of pirica (Fig. 5).
A COPD exacerbation is characterized by an acute worsening of the patient's baseline symptoms including dyspnoea, cough and/or sputum, which may require alteration in regular medication.
However, they may fail to identify occult sources of infection, such as intraabdominal collections and abscesses, the treatment of which may require alteration of empirical treatment or be refractory to antibiotic therapy alone.
Therefore, formation of the bulgy shape in tadpoles may require alteration of the water permeability (i.e., a shutting down of water permeability) of the superficial epidermis of the skin, which might be achieved by expression of pirica (Mori et al., 2009).
They may also require alteration.
Longer trains could be added in some cases but this may require platform alterations or technology that prevents rear doors from opening.
Safe and accessible planning and construction from the start is far less expensive than integrating accessibility features in existing buildings, which may require structural alterations.
Hence, the evolution of an important trait like brain function may require genetic alterations at multiple regulatory levels.
Metastases may require additional alterations after transformation (Fig 4) that allow tumor cells to invade, migrate, and colonize distant sites [ 17].
Some congenital anomalies may require design alteration of the aortic valve.
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