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Those who cannot tolerate iron tablets or solutions may require administration of intravenous iron sucrose, and blood transfusion if the anemia is causing severe symptoms that warrant rapid improvement of the blood count.
Severe and refractory pain may require administration of strong opioids such as oxycodone.
Cardiovascular support during resuscitation may require administration of pharmacologic vasoactive agents with vasopressor and/or inotropic actions after blood volume is restored [ 40].
In addition to mechanical ventilation, some critically ill patients - such as victims of acute spinal cord injury [ 2], of lung transplant rejection [ 3], of hematologic malignancy [ 4] and of status asthmaticus [ 5] - may require administration of high doses of corticosteroids.
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Anaphylactic shock, which can occur in previously sensitized individuals within seconds or minutes, may require immediate administration of epinephrine.
Treatment for PDD-NOS consists primarily of behavioral therapy, though some children may require the administration of medications to stabilize mood or behaviour.
Thus the induction of long-lived mucosal immunity may require vaccine administration directly to the mucosae, especially if the efficient induction of antigen-specific IgA secretion is required [8].
However, our finding that presentation of donor apoptotic cell-derived allopeptides declines 3 days after apoptotic cell infusion indicates that long-term presentation of donor allo-Ag for induction/maintenance of transplant tolerance may require repetitive administration of apoptotic cells.
Combinations with other cytotoxic drugs may require giving administration of PEP005 before cytotoxics with a lag time of 24 h.
Moreover, hypocalcaemia is frequently present in severely injured patients [ 199] and may require the administration of intravenous calcium with frequent ionised serum calcium measurement [ 200].
Moreover, hypocalcemia is frequently present in severely injured patients [ 24] and may require the administration of intravenous calcium, followed by frequent assessment to control serum levels of ionized calcium.
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