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Exact(11)
Its glucose-lowering effects may require activation of AMP-activated protein kinase (AMPK) to inhibit hepatic gluconeogenesis (13), increase peripheral uptake of glucose, and delay gastrointestinal glucose absorption (14).
For sufficiently large spills, the overall Spill Task Force may require activation.
Signaling pathways make use of a range of molecular components, which may require activation in order to transfer the signal to downstream effectors.
Furthermore, some applications may require activation of a spatially dispersed set of neurons over a large area, in which case a single light source may not be adequate.
Regulation of BRCA1 by estrogen may require activation of the MAPK cascade.
Other plausible reason for nuclear GSK3β accumulation may be an additional regulation inside the cell and complete inhibition of GSK3β may require activation of multiple signaling pathways simultaneously.
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Direct stimulation of fibroblasts with TGF- β can induce the transdifferentiation of fibroblasts to myofibroblasts with Erk activation [ 41], which may also require activation of Smad3 [ 40].
Although a single monomer of Cre harbors a complete active site, crystal structures suggest that its functionality may require allosteric activation by a second monomer [6], [25].
A more compatible interaction of PET with acetanilide may require higher activation energy for diffusional jump resulting in more reduction in permeability even though both PET-2.32PET-2.32%tin and PET-1.95% acetanilide showed an equal level of reduction in free volume.
The effect of PBDEs on T4 levels may require metabolic activation because HO-PBDEs, but not the PBDE congeners themselves, behave as ligands for human transthyretin (TTR; a major thyroid hormone transport protein) in vitro (Meerts et al. 2000).
Some developmental toxicity responses may require the activation of a 'persistence detector' to distinguish between short reversible interactions on the one hand and toxicity on the other hand (Lim et al. 2013).
More suggestions(15)
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