Sentence examples for may require accumulation from inspiring English sources

Single dose regimens would also be preferable but the long action of PQ may require accumulation of concentration over three days.

Given that DCL1 has limited or insignificant activity on perfectly-paired dsRNA, acquisition of DCL1-dependence and subsequent formation of discrete small RNA products from the foldback precursor may require accumulation of drift mutations that result in foldback mispairs.

Since Alexa 488-anti-CD147 did not stain a JN spot in these cells, the transport of Abs to CFs apparently does not require accumulation of the Ab in the ERC, suggesting that Ab internalisation may not be required.

These data strongly imply that the normal formation of cross-adaptation response to neurobehavioral toxicity induced by metal exposure may require the enough accumulation of MTs protein in animal tissues.

In many if not all tumors, acquisition of the full cancer phenotype may require the serial accumulation of gain-of-function mutations in oncogenes and loss-of-function mutations in tumor suppressor genes, as well as epigenetic changes.

The authors hypothesize that PTEN loss is associated with strand-break accumulation that may require PNKP-mediated end processing for repair.

Earlier studies have indicated that accumulation of cisplatin in the secretory pathway may require lysosomal function.

If impaired renal function is detected, patients may require a dosage reduction of renally excreted drugs to avoid accumulation and adverse drug reactions [ 15- 17].

Other plausible reason for nuclear GSK3β accumulation may be an additional regulation inside the cell and complete inhibition of GSK3β may require activation of multiple signaling pathways simultaneously.

A molecular mechanism for the intracellular accumulation of OPN under hypoxia has recently been described [ 6, 7], although secretion of OPN may require additional steps [ 8, 9].

That may require legislation.