However, a fundamental aim of ecotoxicity testing is to protect and prevent adverse effects in wild animals, and hence the use of outbred strains has been argued to be more appropriate, as they may better represent wild populations (Brown et al. 2009).
The regionally restricted occurrence of Clades F and G may represent later introgressions of wild yak sequences into the domestic population.
Furthermore, reports of fatal spillover of ADV on captive wild felids and canids after feeding on infected wild boar carcasses suggests that increased ADV occurrence in wild boar may represent a potential threat for protected large carnivores [ 27– 29].
We propose that p53-246 degrees may represent an allosteric variant of wild type p53 compatible with positive growth control.
In addition, the identification of genuinely wild populations may represent a significant evolutionary heritage for the conservation of the Mediterranean olive tree diversity.
One of the most ancient surviving landraces, a giant plant called Mixteco (Zea mays ssp. mays, var. Mixteco), is still grown by Mexican farmers on acidic, nutrient poor soils and may represent a "missing link" between wild teosinte and modern maize [ 35].
In humans, this mechanism may represent a behaviourally relevant remnant of wild life, in which warning and avoidance reaction toward potentially dangerous odorants are building blocks of daily survival.
Therefore, these 'early-generation' hatchery offspring may represent a lower genetic risk to wild populations (Mobrand et al. 2005; Baskett and Waples 2013).
One relevant exception is represented by the G1202R substitution, which was highly resistant to all drugs (>10-fold increased IC50 compared to wild type) and may represent the most challenging mutation to overcome.
The finding motivates the hypothesis that the different experimentally observed TSEs in homologous proteins and circular permutants may represent potentially available pathways to the wild-type protein.
