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Results displayed in Figure 11 may represent testable predictions generated by the model that can be verified by new experimental studies.
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Ultimately, random chance and our proposed explanations represent testable alternative hypotheses that could and should be directly tested.
While the exact mechanism of action for halofantrine in L. major requires further investigation, the model predictions for halofantrine represent testable hypotheses.
We thus suggest that GIRK activation by D2 may represent a mechanism for modulating the properties of Area X neurons, a testable hypothesis that illustrates how molecular findings can help guide targeted pharmacological and electrophysiological studies.
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This hypothesis may be testable with fate mapping and genetic manipulation studies of developing brain circuits.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com