The university hospitals represent tertiary hospitals, the most specialized level of public health care.
Together they represent tertiary referral units serving almost 4 million people, corresponding to 68% of the Danish population.
Interestingly, the three members for which structural studies have been reported are found on separate branches, indicating that the clustering of the Group B members in the dendrogram may represent the three different tertiary structural conformations that they represent.
Covariation in natural evolution reflects the fact that, although not close in primary sequence, distal residues can be adjacent in the tertiary structure and may represent an interaction favourable to protein function.
Transferred patients may represent up to 20% of the admissions in tertiary care intensive care units (ICUs), are known to have a higher severity of illness compared with other ICU patients, and have worse-than-expected ICU outcomes [ 2- 4].
One limitation of the study is that the patients were recruited from a tertiary centre and the patient cohort may represent some selection bias.
These recA sequences are nuclear in location, and may represent nuclear localized copies of endosymbiotic DNA, or may be products of secondary or tertiary endosymbiosis involving protist members.
The study cohort may represent young people with more severe allergy requiring specialist input, since they were recruited from secondary and tertiary allergy centres.
However, data about the frequency and distribution of analogous enzymes suggests that they may represent an untapped resource for such targets, since analogous enzymes share the same activity but possess different tertiary structures, an interesting attribute for drug development.
27 Our cohort, followed at a number of major teaching centres, may represent a lower estimate of damage accrual rates than that seen in general rheumatology practice; conversely, the tertiary referral case mix in many centres may act in the opposite way to influence our estimates.
